Bioinformatic and molecular investigation of Sirt3 expression
نویسندگان
چکیده
Background Fasting and calorie restriction cause significant metabolic changes as organisms try to maintain energy homeostasis. The mitochondrial NAD-dependent protein deacetylase Sirt3 has important metabolic effects, including promotion of fatty acid oxidation during fasting [1] and repression of glycolysis in cancer cells [2]. We sought to investigate the mechanisms by which Sirt3 is transcriptionally induced and regulated using both bioinformatic and molecular methods.
منابع مشابه
Nuclear respiratory factor 2 induces SIRT3 expression
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